BZ Sirotin (Khabarovsk) Among the group of hemorrhagic fever, known in Russia, so far hemorrhagic fever with renal syndrome (HFRS) differs the most widespread, severe, and all still fairly high mortality (2-3%). Some thought that it occurs only in the Far East and not by accident that the first monograph written in 1947, one of the pioneers of studying this disease, my teacher Professor SH.I. Shaw parents has compatible beliefs. Ratner, called 'Clinic e n d e m h e a d of about a hemorrhagic nephroso-Jade' (discharging our). Years passed and it became obvious that disease occurs not only in Russia but also prevalent in many countries in Asia and Europe, as well as a kind of pulmonary syndrome in the Americas. The incidence of HFRS is particularly high in some regions of Russia Bashkortostan, Tatarstan, Udmurtia, and a number of areas of the Volga. It should be noted that in addition to clinically and serologically diagnosed cases of HFRS have a certain percentage of the population of endemic areas revealed antibodies to HFRS, which indicates the existence erased and atypical forms of the disease.
Although there are 8 serotypes of the virus, not all of them cause disease. The main pathogens belong to Hantaan, which causes the most severe form, as well as Seoul, Puumala and Dobrava. Intermediaries for virus transmission to man are different species of wild mice and rats are less houses. The pathogenesis of HFRS is studied far enough, the most important place is occupied by the defeat of the microvasculature, predominantly venular part of it. In essence, HFRS is a viral disease of zoonotic nature, characterized by systemic lesions of small vessels, hemorrhagic diathesis, hemodynamic disorders and a kind of kidney damage in the form of acute tubulointerstitial nephritis, acute renal failure is manifested. Clinic HFRS is extremely bright and dynamic. We distinguish the following clinical syndromes: general toxic, hemodynamic, bleeding, abdominal, neuroendocrine, and acute renal failure.